Identification | Back Directory | [Name]
(S)-methyl 3-(1-benzyl-1H-imidazol-4-yl)-2-(6-(benzyloxy)-5-methoxy-1H-indole-2-carboxamido)propanoate | [CAS]
1598424-76-0 | [Synonyms]
spudl 05650 BMS466442,BMS 466442 L-Histidine, N-[[5-methoxy-6-(phenylmethoxy)-1H-indol-2-yl]carbonyl]-1-(phenylmethyl)-, methyl ester (S)-methyl 3-(1-benzyl-1H-imidazol-4-yl)-2-(6-(benzyloxy)-5-methoxy-1H-indole-2-carboxamido)propanoate | [Molecular Formula]
C31H30N4O5 | [MOL File]
1598424-76-0.mol | [Molecular Weight]
538.59 |
Chemical Properties | Back Directory | [Boiling point ]
827.3±65.0 °C(Predicted) | [density ]
1.26±0.1 g/cm3(Predicted) | [storage temp. ]
-10 to -25°C | [solubility ]
Soluble to 100 mM in DMSO | [form ]
Solid | [pka]
13.15±0.46(Predicted) | [color ]
Off-white to yellow |
Hazard Information | Back Directory | [Biological Activity]
Potent and selective alanine serine cysteine transporter-1 (ASC-1; SLC7A10) inhibitor th at effectively blocks ASC-1-mediated cellular D-Ser uptake.
BMS-466442 is a selective alanine serine cysteine transporter-1 (ASC-1) inhibitor (D-Ser uptake IC50 = 36.8 nM and 19.7 nM using HEK human ASC-1 transfectants or primary r at embryonic cortical culturesrespectively) with good selectivity over >40 other targetsincluding LAT-2 or ASCT-2 (IC50 >10 μM). | [storage]
Store at -20°C |
|
|