| Identification | Back Directory | [Name]
COLLISMYCIN A | [CAS]
158792-24-6 | [Synonyms]
Collismycin
COLLISMYCIN A
(E)-4-Methoxy-5-(methylthio)-[2,2'-bipyridine]-6-carbaldehyde oxime
[2,2'-Bipyridine]-6-carboxaldehyde, 4-methoxy-5-(methylthio)-, oxime, [C(E)]- | [Molecular Formula]
C13H13N3O2S | [MDL Number]
MFCD00921969 | [MOL File]
158792-24-6.mol | [Molecular Weight]
275.33 |
| Chemical Properties | Back Directory | [Melting point ]
173-174 °C | [Boiling point ]
450.7±45.0 °C(Predicted) | [density ]
1.27±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble | [form ]
A solid | [pka]
9.75±0.50(Predicted) |
| Hazard Information | Back Directory | [Uses]
Collismycin A is a microbial product that exhibits anti-proliferative activity against cancer cells. Collismycin A is also an iron chelator and used to develop neuroprotective compounds. | [Uses]
Collismycin is a rare and unusual antibiotic belonging to the caerulomycin class, containing a core 2,2’-bispyridyl with an oxime substituent, produced by a strain of Streptomyces and discovered by researchers from Kirin, Japan in 1994. Collismycin was discovered as a potent inhibitor of glucocorticoid receptor binding. Collismycin has weak to moderate activity against bacteria, fungi and tumor cell lines. More recently, collismycin has been found to be a potent and selective neuroprotective agent against oxidative stress. Other recent publications have focused on the biosynthesis of collismycin as a route to the production of related analogues. | [storage]
Store at -20°C |
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