| Identification | Back Directory | [Name]
D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt) | [CAS]
157542-47-7 | [Synonyms]
D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt)
D-myo-Inositol 1,4,5,6-tetrakis(dihydrogen phosphate) tetrasodium salt | [Molecular Formula]
C6H17NaO18P4 | [MDL Number]
MFCD12912252 | [MOL File]
157542-47-7.mol | [Molecular Weight]
524.07 |
| Hazard Information | Back Directory | [Description]
D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt) (Ins(1,4,5,6)-P4) is one of several different inositol oligophosphate isomers implicated in signal transduction. Production of Ins(1,4,5,6)-P4 by intestinal epithelial cells increases approximately 2-14 fold, depending on the strain and incubation time, following infection with Salmonella.1 Ins(1,4,5,6)-P4 antagonizes epidermal growth factor (EGF) signalling through the phosphatidylinositol 3-kinase pathway.1 Ins(1,4,5,6)-P4 (tested as the D/L racemic mixture) is ~1,000-fold less potent than Ins(1,4,5)-P3 at initiating Ca2+ release when injected into Xenopus oocytes.2 | [References]
1. Eckmann, L., Rudolf, M.T., Ptasznik, A., et al. D-myo-Inositol 1,4,5,6-tetrakisphosphate produced in human intestinal epithelial cells in response to salmonella invasion inhibits phosphoinositide 3-kinase signaling pathways Proc. Natl. Acad. Sci. USA 94,14456-14460(1997).
2. DeLisle, S., Radenberg, T., Wintermantel, M.R., et al. Second messenger specificity of the inositol trisphosphate receptor: Reappraisal based on novel inositol phosphates Am. J. Physiol. 266(2 Pt 1),C429-C436(1994). |
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