| Identification | Back Directory | [Name]
2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid | [CAS]
1572936-83-4 | [Synonyms]
2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid
2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitro-benzoic acid
Benzoic acid, 2-[(4-methoxy-2-naphthalenyl)amino]-5-nitro- | [Molecular Formula]
C18H14N2O5 | [MDL Number]
MFCD28100806 | [MOL File]
1572936-83-4.mol | [Molecular Weight]
338.31 |
| Chemical Properties | Back Directory | [Boiling point ]
553.1±50.0 °C(Predicted) | [density ]
1.421±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml; Ethanol: slightly soluble | [form ]
A crystalline solid | [pka]
2.26±0.22(Predicted) | [color ]
Brown to dark brown |
| Hazard Information | Back Directory | [Description]
MONNA is a selective inhibitor of anoctamin-1 (ANO1; IC50 = 0.08 μM in Xenopus oocytes), a calcium-activated chloride channel (CaCC). It is selective for ANO1 over the chloride channels bestrophin-1, chloride channel protein 2, and cystic fibrosis transmembrane conductance regulator up to 10 μM. MONNA (10 μM) induces full vasorelaxation of preconstricted mouse isolated mesenteric arteries in the presence or absence of chloride. It also hyperpolarizes isolated rat mesenteric arteries under resting conditions. | [Uses]
2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitrobenzoic Acid selectively inhibits the calcium-activated chloride channel, anoctamin-1. 2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitrobenzoic Acid has potential applications for developing treatments for hypertension, cystic fibrosis, bronchitis, asthma, and hyperalgesia. | [storage]
Store at +4°C |
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