| Identification | Back Directory | [Name]
BMY 45778 | [CAS]
152575-66-1 | [Synonyms]
BMY 45778
BMY 45778 >=98% (HPLC)
[3-(4,5-DIPHENYL[2,4'-BIOXAZOL]-5'-YL)PHENOXY]ACETIC ACID
Acetic acid, 2-[3-(4,5-diphenyl[2,4'-bioxazol]-5'-yl)phenoxy]- | [Molecular Formula]
C26H18N2O5 | [MDL Number]
MFCD00917043 | [MOL File]
152575-66-1.mol | [Molecular Weight]
438.43 |
| Chemical Properties | Back Directory | [Boiling point ]
659.9±65.0 °C(Predicted) | [density ]
1.298±0.06 g/cm3(Predicted) | [storage temp. ]
room temp | [solubility ]
≥67.6 mg/mL in DMSO | [form ]
powder | [pka]
3.10±0.10(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
BMY 45778 is an agonist for IP receptor to up-regulate the expression of C?/EBPβ and C?/EBPδ. | [Definition]
ChEBI: BMY 45778 is a bisoxazole. It has a role as a partial prostacyclin agonist. | [Biological Activity]
Non-prostanoid prostacyclin mimetic that acts as a partial agonist at IP 1 prostacyclin receptors. Potently inhibits platelet aggregation in vitro (IC 50 = 27-35 nM). | [Biochem/physiol Actions]
BMY 45778 is a non-prostanoid prostacyclin agonist. | [References]
[1]. seiler sm, brassard cl, federici me, et al. [3-[4-(4,5-diphenyl-2-oxazolyl)-5-oxazolyl]phenoxy]acetic acid (bmy 45778) is a potent non-prostanoid prostacyclin partial agonist: effects on platelet aggregation, adenylyl cyclase, camp levels, protein kinase, and iloprost binding. prostaglandins, 1997, 53(1): 21-35.
[2]. wise h, qian ym, jones rl. a study of prostacyclin mimetics distinguishes neuronal from neutrophil ip receptors. eur j pharmacol, 1995, 278(3): 265-269. |
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