| Identification | Back Directory | [Name]
KDU691 | [CAS]
1513879-19-0 | [Synonyms]
KDU691
KDU691 >=98% (HPLC)
KDU691;KDU-691;KDU 691;1513879-19-0
Imidazo[1,2-a]pyrazine-6-carboxamide, N-(4-chlorophenyl)-N-methyl-3-[4-[(methylamino)carbonyl]phenyl]- | [Molecular Formula]
C22H18ClN5O2 | [MOL File]
1513879-19-0.mol | [Molecular Weight]
419.86 |
| Chemical Properties | Back Directory | [density ]
1.35±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:PBS (pH 7.2) (1:9):0.1(Max Conc. mg/mL);0.24(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);23.82(Max Conc. mM) | [form ]
A crystalline solid | [pka]
14.59±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
KDU691 is an antimalarial compound.1 It inhibits recombinant P. vivax phosphatidylinositol 4-kinase (PI4K) with an IC50 value of 1.5 nM. KDU691 is selective for P. vivax PI4K over recombinant human PI4KβIII and PI3Kα, -β, -γ, and -δ (IC50s = 7.9, 8.8, 2.4, 8, and 3.4 μM, respectively), as well as VPS34 (IC50 = >9.7 μM) and 36 additional kinases in a panel of lipid and protein kinases (IC50s = >10 μM). It is active against P. falciparum and P. yoelii schizonts (IC50s = 0.06 and 0.04 μM, respectively), as well as P. cynomolgi schizonts and hypnozoites (IC50s = 0.11 and 0.2 μM, respectively).2 KDU691 completely prevents, but does not eradicate established, P. cynomolgi infection in rhesus monkeys when administered at a dose of 20 mg/kg.3 | [Uses]
KDU691, is a PI4K inhibitor. | [storage]
Store at -20°C |
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Twochem Co.Ltd.
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021-58111628 15800915896 |
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cn.twochem.com |
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BOC Sciences
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https://www.bocsci.com |
| Company Name: |
DC Chemicals
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021-58447131 13564518121 |
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http://www.approvedhomemanagement.com/ShowSupplierProductsList927327/0.htm |
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