| Identification | Back Directory | [Name]
2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole | [CAS]
150493-34-8 | [Synonyms]
NS 638
NS638, >98%
NS-638;NS 638
2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole
1-[(4-Chlorophenyl)Methyl]-5-(Trifluoromethyl)Benzimidazol-2-Amine
1H-Benzimidazol-2-amine,1-[(4-chlorophenyl)methyl]-5-(trifluoromethyl)- | [Molecular Formula]
C15H11ClF3N3 | [MOL File]
150493-34-8.mol | [Molecular Weight]
325.72 |
| Chemical Properties | Back Directory | [Boiling point ]
476.3±55.0 °C(Predicted) | [density ]
1.45±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 5 mg/ml; DMSO: 5 mg/ml; Ethanol: 2 mg/ml; PBS (pH 7.2): insol | [form ]
A solid | [pka]
5.15±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Biological Activity]
NS-638 is a non-peptidic small molecule with Ca2+-ion channel blocking properties. The IC50 value for intracellular blocking of the increase in Ca2+ concentration activated by K+ was 3.4 μM. | [in vivo]
In the mouse middle cerebral artery occlusion model, NS-638 administered ip (50 mg kg-1) at 1 h and 6 h post-ischemia, and once a day for the next two days, results in a 48% reduction in total infarct volume. It does not show protection against ischemic neuronal damage in the gerbil model of bilateral carotid artery occlusion. | [target]
IC50: 3.4 μM (K + -stimulated intracellular Ca 2+ -elevation) | [storage]
Store at -20°C |
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