Identification | Back Directory | [Name]
HUMAN IL-13 | [CAS]
148157-34-0 | [Synonyms]
ALRH BHR1 P600 IL-13 RHIL-13 HUMAN NC30 Aids059207 Aids-059207 HUMAN IL-13 IL-13, HUMAN INTERLEUKIN 13 IL-13 from rat IL-13 Variant human Human IL-13 Protein HUMAN INTERLEUKIN 13 INTERLEUKIN-13, HUMAN RECOMBINANT HUMAN IL-13 IL-13 Long Form from rat Interleukin-13 from mouse NC300 (Human) P600 (Murine) Interleukin-13, Human, Recomb. Mouse Interleukin 13 elisa kit INTERLEUKIN-13, HUMAN, RECOMBINANT Recombinant Human IL13 Protein, Fc Tag INTERLEUKIN-13 (IL-13), HUMAN, RECOMBINANT Interleukin-13, Human, Recombinant, E. coli Recombinant Mouse Il-13/Il13 Protein, No Tag Recombinant Mouse Il-13/Il13 Protein, His Tag Gpvppstalrelieelvnitqnqkaplcngsmvwsinltagmycaaleslinvsgcsaiektqrmlsgfcphkvsagqfsslhvrdtkievaqfvkdlllhlkklfregrfn Interleukin-13 human >=97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, cell culture tested | [MDL Number]
MFCD00212209 |
Hazard Information | Back Directory | [General Description]
Interleukin-13 (IL-13) is an immunoregulatory cytokine produced primarily by activated T-helper 2 (Th2) cells,and also by mast cells and natural killer (NK) cells. The gene encoding it is localized on human chromosome 5q31. Human and murine IL-13 is cross-species reactive. Recombinant human IL-13 is a 12.6kDa protein consisting of 115 amino acid residues. | [Biochem/physiol Actions]
Interleukin-13 (IL-13) has a role in immune activities against infections and influences the function of various cells taking part in the same. It has been studied to be overexpressed in glioblastoma tumors and cell lines. IL-13 stimulates fibrosis in many infectious diseases. Targeted deletion of IL-13 in mice resulted in impaired T-helper 2 (Th2) cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukins-1β, -6 and -8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of immunoglobulin E (IgE). Blocking of IL-13 activity inhibits the pathophysiology of asthma. |
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