| Identification | Back Directory | [Name]
sulforidazine | [CAS]
14759-06-9 | [Synonyms]
sulforidazine
Thioridazine 2-Sulfone
Thioridazine EP Impurity E
Thioridazine Impurity 5 (Thioridazine EP Impurity E)
10H-Phenothiazine, 10-[2-(1-methyl-2-piperidinyl)ethyl]-2-(methylsulfonyl)-
10-[2-[(2RS)-1-Methylpiperidin-2-yl]ethyl]-2-(methylsulfonyl)-10H-phenothiazine | [EINECS(EC#)]
238-818-7 | [Molecular Formula]
C21H26N2O2S2 | [MOL File]
14759-06-9.mol | [Molecular Weight]
402.57 |
| Chemical Properties | Back Directory | [Melting point ]
121-123° | [Boiling point ]
589.1±50.0 °C(Predicted) | [density ]
1?+-.0.06 g/cm3(Predicted) | [storage temp. ]
Refrigerator, Under Inert Atmosphere | [solubility ]
Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
9.83±0.10(Predicted) | [color ]
Off-White to Dark Yellow |
| Hazard Information | Back Directory | [Chemical Properties]
Thick Yellow Oil | [Originator]
Sulforidazine,ZYF Pharm Chemical | [Uses]
A major metabolite of Thioridazine (THD 2-SO2). | [Uses]
Thioridazine 2-Sulfone (Thioridazine EP Impurity E) is a major metabolite of Thioridazine (THD 2-SO2). | [Definition]
ChEBI: Sulforidazine is a member of phenothiazines. | [Manufacturing Process]
A mixture of 96.5 g 2-methylsulfonylphenothiazine, 50 g 2-(2-chloroethyl)-1-
methylpiperidine, 62 g diethyl carbonate and 2 g sodium methylate was
heated at 135°C for 1 hour and then at 180-190°C for 2.5 hours. The product
was dissolved in benzene (500 ml) and the solution was extracted with 700 ml
of 15% aqueous solution tartaric acid. The extract was washed with benzene.
After addition of sodium carbonate solution to the extract was obtained a
precipitate which was dissolved in benzene. This solution was washed with
water and concentrated. 2-Methylsulfonyl-10-(2-(1-methyl-2-
piperidyl)ethyl)phenothiazin was recrystallized from acetone, melting point
121-123°C. | [Therapeutic Function]
Neuroleptic |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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