| Identification | Back Directory | [Name]
Z-NH-5(ethylene glycol)-acetic acid | [CAS]
1449390-66-2 | [Synonyms]
CbzNH-P5-CH2CO2H
Z-NH-PEG5-CH2COOH
CBZ-NH-PEG5-CH2COOH
CBZ-NH-PEG5-acetic acid
Z-NH-5(ethylene glycol)-acetic acid
5,8,11,14,17-Pentaoxa-2-azanonadecanedioic acid, 1-(phenylmethyl) ester | [Molecular Formula]
C20H31NO9 | [MDL Number]
MFCD31656969 | [MOL File]
1449390-66-2.mol | [Molecular Weight]
429.46 |
| Hazard Information | Back Directory | [Biological Activity]
Cbz-NH-PEG5-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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