| Identification | Back Directory | [Name]
[3-(Trifluoromethyl)phenyl]methyl (2S)-5-oxooxolane-2-carboxylate | [CAS]
1445703-64-9 | [Synonyms]
TFMB(S)2HG
TFMB S 2 HG
TFMB-S-2-HG
TFMB-(S)-2-HG
TFMB (S) 2 HG
[3-(Trifluoromethyl)phenyl]methyl (2S)-5-oxooxolane-2-carboxylate | [Molecular Formula]
C13H11F3O4 | [MDL Number]
MFCD31657511 | [MOL File]
1445703-64-9.mol | [Molecular Weight]
288.22 |
| Chemical Properties | Back Directory | [Boiling point ]
376.3±42.0 °C(Predicted) | [density ]
1.385±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
Solid | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Biological Activity]
TFMB-(S)-2-HG is a potent inhibitor of the 5'-methylcytosine hydroxylase TET2. TFMB-(S)-2-HG also inhibits the EglN prolyl hydroxylases. TFMB-(S)-2-HG has the potential for the research of acute myeloid leukemia (AML)[1]. | [References]
[1]. Losman JA, et al. (R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible. Science. 2013;339(6127):1621-1625. |
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