| Identification | Back Directory | [Name]
19-Epi FK-506 | [CAS]
144490-63-1 | [Synonyms]
19-Epi FK-506
Ascomycin 19 epimer
Tacrolimus 19-epimer
Tacrolimus Impurity 6
Tacrolimus EP Impurity G
ascomycin epimeric 19 body
QJJXYPPXXYFBGM-VIJOMOBOSA-N
19-Epi FK-506 (Tacrolimus Impurity)
tacrolimus difference SECRETARY 19 epimers
Tacrolimus Impurity 8（Tacrolimus EP Impurity G）（Tacrolimus 19-Epimer）
1,14-dihydroxy-12-[1-(4-hydroxy-3-methoxycyclohexyl)prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-17-prop-2-enyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone | [Molecular Formula]
C44H69NO12 | [MOL File]
144490-63-1.mol | [Molecular Weight]
804.03 |
| Chemical Properties | Back Directory | [Boiling point ]
871.7±75.0 °C(Predicted) | [density ]
1.19±0.1 g/cm3(Predicted) | [pka]
9.97±0.70(Predicted) | [InChI]
InChI=1/C44H69NO12/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3/b25-19-,27-21+/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44-/s3 | [InChIKey]
QJJXYPPXXYFBGM-ZADLGOIHNA-N | [SMILES]
O([C@H]1C[C@@H](C)[C@]2(C(C(N3CCCC[C@@]3([H])C(O[C@@H]([C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)C=C(C)C[C@H](C)C[C@H](OC)[C@@]1([H])O2)/C(/C)=C/[C@@H]1CC[C@@H](O)[C@H](OC)C1)=O)=O)=O)O)C |t:30,&1:1,3,5,13,17,18,20,25,33,36,39,45,48,50,r| |
| Hazard Information | Back Directory | [Uses]
19-Epi FK-506 is an impurity in the synthesis of FK-506 [Tacrolimus] (F370000), an immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release. | [Uses]
19-Epi FK-506 is an impurity in the synthesis of FK-506 [Tacrolimus] (F370000), an immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release. |
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| Company Name: |
BOC Sciences
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| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
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