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ChemicalBook--->CAS DataBase List--->14362-31-3

14362-31-3

14362-31-3 Structure

14362-31-3 Structure
IdentificationBack Directory
[Name]

CHLORCYCLIZINE HYDROCHLORIDE
[CAS]

14362-31-3
[Synonyms]

eramide
Perazil
NSC 169496
di-paralene
CHLORCYCLIZINE HCL
Ah-289 hydrochloride
Component of fedrazil
chlorcycliziniumchloride
CHLORCYCLIZINE HYDROCHLORIDE
Chlorocyclizine hydrochloride
Chlorcyclizine hydrochloride CRS
1-(p-chlorobenzhydryl)-4-methylpiperazinehydrochloride
1-(4-CHLORODIPHENYLMETHYL)-4-METHYLPIPERAZINE HYDROCHLORIDE
1-(p-chloro-alpha-phenylbenzyl)-4-methylpiperazinehydrochloride
1-(p-chloro-alpha-phenylbenzyl)-4-methyl-piperazinhydrochloride
1-(p-Chloro-α-phenylbenzyl)-4-Methylpiperazine Monohydrochloride
1-[(4-CHLOROPHENYL)PHENYL-METHYL]-4-METHYLPIPERAZINE HYDROCHLORIDE
1-[(4-Chlorophenyl)phenylmethyl]-4-methylpiperazine monohydrochloride
[EINECS(EC#)]

238-335-1
[Molecular Formula]

C18H22Cl2N2
[MDL Number]

MFCD00035329
[MOL File]

14362-31-3.mol
[Molecular Weight]

337.29
Chemical PropertiesBack Directory
[Melting point ]

226-227 °C
[storage temp. ]

Store at -20°C
[solubility ]

≥11 mg/mL in DMSO with gentle warming; ≥14.7 mg/mL in EtOH; ≥9.44 mg/mL in H2O with ultrasonic
[form ]

neat
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

An antihistaminic drug
[Biological Activity]

chlorcyclizine is a phenylpiperazine antagonist for histamine h1 receptor [1].the histamine has been involved in modulating many physiological functions of the hypothalamus, such as arousal state, feeding, locomotor activity, and drinking. histamine has been involved in circadian rhythm of locomotor activity and exploratory behavior through h1r [1].
[in vitro]

the ki value of chlorcyclizine for histamine h1 receptor was 9 nm [1]. chlorcyclizin was effective against hepatitis c virus (hcv) with an ec50 of 44 nm, preventing viral entry into host cells [2].
[in vivo]

in chimeric mice xenografted with primary human hepatocytes, chlorcyclizine (10-50 mg/kg) significantly inhibited infection of hcv genotypes 1b and 2a [2]. chlorcyclizine induced a resistance to sodium pentobarbital anesthesia. intraperitoneal injection of chlorcyclizine showed a sedative effect in small doses, but a convulsive effect in large doses. intraperitoneal injections of the drug did not affect the recovery time from pentobarbital anesthesia [3]. in rats, pretreatment with chlorcyclizine for several days shortened the duration of action of a subsequent dose of hexobarbital, pentobarbital or zoxazolamine, and accelerated in vivo metabolism of hexobarbital [4]. the administration of chlorcyclizine (50 g/kg) to rats by stomach tube daily for 1 week resulted in significant increases in liver weight, microsomal protein concentration and the activity of the nadph-dependent hepatic microsomal ethanol-oxidizing system (meos) [5].
[storage]

Store at -20°C
[References]

[1] tran v t, chang r s, snyder s h. histamine h1 receptors identified in mammalian brain membranes with [3h] mepyramine[j]. proceedings of the national academy of sciences, 1978, 75(12): 6290-6294.
[2] he, s. ,xiao, j.,dulcey, a.e., et al. discovery, optimization, and characterization of novel chlorcyclizine derivatives for the treatment of hepatitis c virus infection. journal of medicinal chemistry 59(3), 841-853 (2016).
[3] thompson i d, dolowy w c, cole w h. development of a resistance to sodium pentobarbital in rats fed on a diet containing chlorcyclizine hydrochloride[j]. journal of pharmacology and experimental therapeutics, 1959, 127(2): 164-166.
[4] conney a h, burns j j, michaelson i a. stimulatory effect of chlorcyclizine on barbiturate metabolism[j]. journal of pharmacology and experimental therapeutics, 1961, 132(2): 202-206.
[5] khanna j m, kalant h, lin g. significance in vivo of the increase in micro-somal ethanol-oxidizing system after chronic administration of ethanol, pheno-barbital and chlorcyclizine[j]. biochemical pharmacology, 1972, 21(16): 2215-2226.
Safety DataBack Directory
[Hazard Codes ]

T
[Risk Statements ]

61-22
[Safety Statements ]

53-22-36/37/39-45
[RIDADR ]

UN 2811 6.1 / PGIII
[Safety Profile]

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits very toxic fumes of HCl and NOx.
[Toxicity]

cat,LD50,intraperitoneal,75mg/kg (75mg/kg),"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 213, 1972.
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Ethanol-->Hydrochloric acid-->Diethyl ether-->Sulfuric acid-->Sodium carbonate-->Sodium sulfate-->Sodium bicarbonate-->1-Methylpiperazine-->P-XYLENE-->4-Chlorobenzhydrol
Spectrum DetailBack Directory
[Spectrum Detail]

CHLORCYCLIZINE HYDROCHLORIDE(14362-31-3)MS
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