| Identification | Back Directory | [Name]
PF-06281355 | [CAS]
1435467-38-1 | [Synonyms]
PF-1355
PF-06281355
PF-06281355 (Free base)
PF-06281355 >=98% (HPLC)
PF06281355;PF1355;PF 1355;PF-06281355;PF 06281355
6-(2,5-Dimethoxyphenyl)-3,4-dihydro-4-oxo-2-thioxo-1(2H)-pyrimidineacetamide
1(2H)-Pyrimidineacetamide, 6-(2,5-dimethoxyphenyl)-3,4-dihydro-4-oxo-2-thioxo-
2-(6-(2,5-dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide | [Molecular Formula]
C14H15N3O4S | [MDL Number]
MFCD29472589 | [MOL File]
1435467-38-1.mol | [Molecular Weight]
321.35 |
| Chemical Properties | Back Directory | [density ]
1.43±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 10mg/mL; DMF:PBS (pH 7.2) (1:1): 0.5mg/mL; DMSO: 10mg/mL; Ethanol: 5mg/mL | [form ]
A crystalline solid | [pka]
6.93±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
PF-1355 is a selective 2-thiouracil mechanism-based MPO inhibitor, used for treatment of vasculitic diseases. | [Biological Activity]
PF-06281355 (PF-1355) is an orally availableselective and potent mechanism based inhibitor of the myeloperoxidase (MPO) th at reduces plasma MPO activityvascular edemaneutrophil recruitmentand elevated circulating cytokines. PF-06281355 suppresses albuminuria and chronic renal dysfunction in model of anti-Glomerular Basement Membrane (GBM) disease. | [in vivo]
Oral administration of PF-1355 reduces plasma MPO activity, vascular edema, neutrophil recruitment, and elevates circulating cytokines. In a model of anti-glomerular basement membrane disease, formerly known as Goodpasture disease, albuminuria and chronic renal dysfunction are completely suppressed by PF-1355 treatment[1]. | [storage]
Store at -20°C | [References]
[1] Zheng W, et al. PF-1355, a mechanism-based myeloperoxidase inhibitor, prevents immune complex vasculitis and anti-glomerular basement membrane glomerulonephritis. J Pharmacol Exp Ther. 2015 May;353(2):288-98 DOI:10.1124/jpet.114.221788 |
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| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
| Company Name: |
DC Chemicals
|
| Tel: |
021-58447131 13564518121 |
| Website: |
http://www.approvedhomemanagement.com/ShowSupplierProductsList927327/0.htm |
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