143370-84-7

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143370-84-7 Structure

Identification	Back Directory
[Name] Bryostatin 3
[CAS] 143370-84-7
[Synonyms] Bryostatin 3 >=95% (HPLC) 2,4-Octadienoic acid, (4S,5S,7E,9R,11Z,13S,15S,17S,19R,21R,25R,27R,27aS)-17-(acetyloxy)-4,5,6,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,25,26,27,27a-docosahydro-5,15,21-trihydroxy-25-[(1R)-1-hydroxyethyl]-11-(2-methoxy-2-oxoethylidene)-6,6,16,16-tetramethyl-2,23-dioxo-5,27:9,13:15,19-triepoxy-2H-f... (4S,5S,7E,9R,11Z,13S,15S,17S,19R,21R,25R,27R,27aS)-17-(Acetyloxy)-4,5,6,9,10,11,12,13,14,15,16,17,18,19, 20,21,22,23,25,26,27,27a-docosahydro-5,15,21-trihydroxy-25-[(1R)-1-hydroxyethyl]-11-(2-methoxy-2-oxoethylidene)-6,6,16,16-tetramethyl-2,23-dioxo-5,27:9,13:15,19-triepoxy-2H-furo[2,3-e]oxacyclohexacosin-4-yl-(2E,4E)-2,4-octadienoic acid ester
[Molecular Formula] C46H64O17
[MDL Number] MFCD09838098
[MOL File] 143370-84-7.mol
[Molecular Weight] 888.99

Chemical Properties	Back Directory
[Boiling point ] 993.2±65.0 °C(Predicted)
[density ] 1.31±0.1 g/cm3(Predicted)
[storage temp. ] Store at -20°C
[solubility ] Soluble in ethanol
[form ] film
[pka] 10.72±0.70(Predicted)
[color ] colorless to light yellow
[biological source] Bugula neritina (sponge)

Hazard Information	Back Directory
[Uses] Bryostatin 3, a macrocyclic lactone, is a protein kinase C activator, with a Ki of 2.75 nM. Bryostatin 3 can block 12-O-tetradecanoylphorbol-13-acetate (TPA) inhibition of cell proliferation, yet did not block TPA-enhanced cell-substratum adhesion[1][2].
[Biological Activity] Bryostatin 3 is a potent protein kinase C activator with a Ki of 2.75 nMand an antagonist to phorbol ester tumor promoter TPA. Bryostatin 3 is isolated from the bryozoan Bugula neritina.
[storage] Store at -20°C
[References] [1] Wender PA, et, al. Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase C. Proc Natl Acad Sci U S A. 1988 Oct;85(19):7197-201. DOI:10.1073/pnas.85.19.7197 [2] Mackanos EA, et, al. Bryostatins selectively regulate protein kinase C-mediated effects on GH4 cell proliferation. J Biol Chem. 1991 Jun 15;266(17):11205-12. PMID:1904062

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Company Name:	MedBioPharmaceutical Technology Inc
Tel:	021-69568360 18916172912
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Company Name:	Nantong QuanYi Biotechnology Co., Ltd
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