| Identification | Back Directory | [Name]
Thieno[3,2-d]pyriMidine-6-carboxaMide, 4-[4-[2-[(2,2-diMethyl-1-oxopropyl)aMino]ethyl]-1-piperidinyl]- | [CAS]
1431411-60-7 | [Synonyms]
SIRT-IN-1
Inhibitor,Sirtuin,SIRT IN 1,SIRTIN1,inhibit
4-[4-[2-(2,2-dimethylpropanoylamino)ethyl]piperidin-1-yl]thieno[3,2-d]pyrimidine-6-carboxamide
4-[4-[2-[(2,2-dimethyl-1-oxopropyl)amino]ethyl]-1-piperidinyl]-Thieno[3,2-d]pyrimidine-6-carboxamide
Thieno[3,2-d]pyriMidine-6-carboxaMide, 4-[4-[2-[(2,2-diMethyl-1-oxopropyl)aMino]ethyl]-1-piperidinyl]- | [Molecular Formula]
C19H27N5O2S | [MDL Number]
MFCD28386339 | [MOL File]
1431411-60-7.mol | [Molecular Weight]
389.515 |
| Hazard Information | Back Directory | [Description]
SIRT-IN-1 is a potent inhibitor of SIRT1/2/3, with IC50s of 15, 10, 33 μM, respectively. SIRT-IN-1 (compound 28) is one of the most potent truncated pan SIRT1/ 2/3 inhibitor, the IC50 values are 0.015, 0.010, 0.033 μM, respectively. SIRT-IN-1 (SIRT1/2/3 pan inhibitor) binds identically in the catalytic active site (RMS=0.29 ?), occupying the nicotinamide C-pocket and acetyl lysine substrate channel[1]. | [References]
[1]. Disch JS, et al. Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3. J Med Chem. 2013 May 9;56(9):3666-79. |
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