| Identification | Back Directory | [Name]
HJC-0123 | [CAS]
1430420-02-2 | [Synonyms]
HJC-0123
4-Quinolinecarboxamide, N-(1,1-dioxidobenzo[b]thien-6-yl)-2-phenyl- | [Molecular Formula]
C24H16N2O3S | [MOL File]
1430420-02-2.mol | [Molecular Weight]
412.46 |
| Hazard Information | Back Directory | [Description]
Downregulate phosphorylation of STAT3, increase the expression of cleaved caspase-3, inhibit cell cycle progression and promote apoptosis in breast and pancreatic cancer cells with low micromolar to nanomolar IC50 values. Furthermore, HJC-0123 significantly suppressed estrogen receptor (ER)-negative breast cancer MDA-MB-231 xenograft tumor growth in vivo (p.o.), indicating its great potential as an efficacious and orally bioavailable drug candidate for human cancer therapy. |
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