| Chemical Properties | Back Directory | [Boiling point ]
726.0±70.0 °C(Predicted) | [density ]
1.660±0.06 g/cm3(Predicted) | [solubility ]
DMSO : 62.5 mg/mL (143.58 mM; Need ultrasonic) | [form ]
Solid | [pka]
5.86±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Biological Activity]
SGK1-IN-2 (14h) is a selective SGK1 (serum and glucocorticoid regulated kinase 1) inhibitor, with an IC50 of 5 nM at 10 μM ATP concentration[1]. | [References]
[1]. Halland N, et al. Discovery of N-[4-(1H-Pyrazolo[3,4-b]pyrazin-6-yl)-phenyl]-sulfonamides as Highly Active and Selective SGK1 Inhibitors. ACS Med Chem Lett. 2014 Oct 23;6(1):73-8. |
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