| Identification | Back Directory | [Name]
GSK2795039 | [CAS]
1415925-18-6 | [Synonyms]
GSK2795039
GSK-2795039
(GSK 2795039
N-(1-isopropyl-3-(1-methylindolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-methyl-1H-pyrazole-3-sulfonamide
1H-Pyrazole-3-sulfonamide, N-[3-(2,3-dihydro-1-methyl-1H-indol-6-yl)-1-(1-methylethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-methyl- | [Molecular Formula]
C23H26N6O2S | [MDL Number]
MFCD30489720 | [MOL File]
1415925-18-6.mol | [Molecular Weight]
450.56 |
| Chemical Properties | Back Directory | [Boiling point ]
691.5±65.0 °C(Predicted) | [density ]
1.39±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMF:30.0(Max Conc. mg/mL);66.58(Max Conc. mM)
DMSO:66.27(Max Conc. mg/mL);147.07(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.44(Max Conc. mM)
Ethanol:20.0(Max Conc. mg/mL);44.39(Max Conc. mM) | [form ]
A solid | [pka]
6.99±0.30(Predicted) | [color ]
White to yellow | [InChIKey]
FMWVTCZKCXPKFW-UHFFFAOYSA-N | [SMILES]
N1(C)C=CC(S(NC2C=CN=C3N(C(C)C)C=C(C4=CC5=C(C=C4)CCN5C)C3=2)(=O)=O)=N1 |
| Hazard Information | Back Directory | [Biological Activity]
GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) with pIC50 of 6.57 for NOX2-mediated activation of HRP/Amplex Red. It inhibits reactive oxygen species (ROS) production, NADPH depletion and reduces apoptosis. | [in vitro]
GSK2795039 (25 μM; 24 hours) reduces the combinatory effect of FeSO4 and LPS-increased levels of apoptosis and reduced the presence of caspase-3-positive PC12 cells. Apoptosis Analysis p> | Cell Line: | PC12 cells | < td class="col1"> Concentration: | 25 μM | | Incubation Time: | < td class="col2"> 24 hours | Result: | Reduced apoptosis among PC12 cells. | td> | [target]
| Target | Value | ROS
() | | NADPH
() | | NOX2 (HRP/Amplex Red)
(Cell-based assay) | 6.57( pIC50) |
| [storage]
Store at -20°C |
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