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ChemicalBook--->CAS DataBase List--->1412905-18-0

1412905-18-0

1412905-18-0 Structure

1412905-18-0 Structure
IdentificationBack Directory
[Name]

HC≡C-CH2-PEG3-SH
[CAS]

1412905-18-0
[Synonyms]

HC≡C-CH2-PEG3-SH
Propargyl-PEG3-SH
[Molecular Formula]

C9H16O3S
[MDL Number]

MFCD31747070
[MOL File]

1412905-18-0.mol
[Molecular Weight]

204.29
Hazard InformationBack Directory
[Biological Activity]

Propargyl-PEG3-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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