| Identification | Back Directory | [Name]
NOGALAMYCIN | [CAS]
1404-15-5 | [Synonyms]
U 15167
U-15167
nsc-70845
AIDS031122
nogalomycin
NOGALAMYCIN
Nogalamyicn
Nogalamycine
Nogalamycinum
antibiotic205t3
antibioticnsc70845
NOGALAMYCIN, STREPTOMYCES NOGALATER
NOGALAMYCIN FROM STREPTOMYCES NOGALATER
Nogalamycin >=95%, from Streptomyces nogalater | [Molecular Formula]
C39H49NO16 | [MDL Number]
MFCD00083442 | [MOL File]
1404-15-5.mol | [Molecular Weight]
787.8 |
| Chemical Properties | Back Directory | [Melting point ]
195-196° (dec) | [alpha ]
D25 +425° (c = 0.11 in CHCl3) | [Boiling point ]
658.61°C (rough estimate) | [density ]
1.2095 (rough estimate) | [refractive index ]
1.7650 (estimate) | [storage temp. ]
2-8°C | [solubility ]
DMF: Soluble; DMSO: Soluble; Ethanol: soluble; Methanol: Soluble | [form ]
A solid | [pka]
7.45 (60% ethanol) | [color ]
Orange-red solid from MeOH | [biological source]
Streptomyces nogalater |
| Hazard Information | Back Directory | [Uses]
Nogalamycin (cas# 1404-15-5) is a compound useful in organic synthesis. | [Uses]
Nogalamycin is an unusual anthracycline produced by Streptomyces nogalater var. nogalater, reported by researchers at Upjohn in 1965. Nogalamycin contains two saccharides. The neutral monosaccharide attaches to the D ring, similar to the aminoglycoside moieties of the doxorubicin class, while the second, basic saccharide attaches to the phenolic group on the A ring in the ortho position to form a unique family of hexacyclic anthracyclines. Nogalamycin is potent antibacterial and antitumor agent that interacts with DNA by intercalation. | [Definition]
ChEBI: Nogalamycin is an anthracycline antibiotic isolated from Streptomyces nogalater. It is a DNA intercalator and exhibits anticancer properties. It has a role as an antineoplastic agent, a cardiotoxic agent, a bacterial metabolite and an intercalator. It is a methyl ester, a polyketide, an anthracycline antibiotic, a tertiary amino compound, a monosaccharide derivative, an organic heterohexacyclic compound and a tetrol. | [Biochem/physiol Actions]
Anthracyclic antitumor antibiotic. | [Safety Profile]
Poison by intravenous andintraperitoneal routes. Human mutation data reported. Anantibiotic. When heated to decomposition it emits toxicfumes of NOx. | [in vivo]
Nogalamycin (0-1000 mug/kg; IP) can regress chemically-induced fibrosarcoma tumors and tumors of spontaneous origin in rats[3]. | Animal Model: | Rats[1] | | Dosage: | 0-1000 mug/kg | | Administration: | IP | | Result: | Regressed chemically-induced fibrosarcoma tumors and tumors of spontaneous origin in rats, and the most effective concentration was 556 mug/kg. |
| [storage]
Store at -20°C |
|
| Company Name: |
T&W GROUP
|
| Tel: |
021-61551611 13296011611 |
| Website: |
www.trustwe.com/ |
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Lynnchem
|
| Tel: |
86-(0)29-85992781 17792393971 |
| Website: |
http://www.lynnchem.com/ |
| Company Name: |
Novachemistry
|
| Tel: |
44-20819178-90 02081917890 |
| Website: |
https://www.novachemistry.com/ |
|