| Identification | Back Directory | [Name]
Pyridine, 3-methoxy-2,6-dimethyl-4-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methoxy]- | [CAS]
139958-16-0 | [Synonyms]
ME3221
ME-3221
ME 3221
Pyridine, 3-methoxy-2,6-dimethyl-4-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methoxy]- | [Molecular Formula]
C22H21N5O2 | [MOL File]
139958-16-0.mol | [Molecular Weight]
387.43 |
| Hazard Information | Back Directory | [Description]
ME-3221 is an angiotensin type 1 receptor antagonist potentially for the treatment of hypertension. ME3221 prevents hypertensive complications in aged stroke-prone spontaneously hypertensive rats. n rats and marmosets, ME3221 antagonized angiotensin II-induced pressor responses, but did not affect bradykinin-induced depressor responses. ME3221 lowered the blood pressure in renal hypertensive rats and spontaneously hypertensive rats (SHR), and its ED25 value was 3 times that of losartan. |
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