| Identification | Back Directory | [Name]
1R,2R-(+)-1-phenyl-2-palMitoylaMino-3-N-Morpholine-1-propanol | [CAS]
139889-53-5 | [Synonyms]
D-threo-PPMP (PPMP)
1R,2R-(+)-1-phenyl-2-palMitoylaMino-3-N-Morpholine-1-propanol
N-[(1R,2R)-2-hydroxyl-1-(4-monopholinylmethyl)-2-phenylethyl]decanamid
1R,2R-(+)-1-PHENYL-2-PALMITOYLAMINO-3-N-MORPHOLINE-1-PROPANOL;D-THREO-PPMP
Hexadecanamide, N-[(1R,2R)-2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]- | [Molecular Formula]
C29H50N2O3 | [MDL Number]
MFCD22495353 | [MOL File]
139889-53-5.mol | [Molecular Weight]
474.72 |
| Hazard Information | Back Directory | [Description]
D-threo-PPMP also known as 1R,2R-(+)-1-phenyl-2-palmitoylamino-3-N-morpholine-1-propanol, is a bioactive sphingolipid. It plays a vital role in regulation of ceramide metabolism. D-threo-PPMP influences cytokinesis failure and glycosylation by inhibiting glucosyl ceramide synthase (GCS). D-threo-PPMP also stops acylation reaction by inhibiting the activity of 1-O-acylceramide synthase (1-O-ACS). | [in vitro]
On the other hand, D-threo-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol (PPMP), an inhibitor of glucosylceramide synthesis, blocked karyokinesis and reduced cyst production in culture. PPMP also altered the expression of cyst wall protein transcripts in encysting cells._x000D_
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Reference: Infect Immun. 2008 Jul;76(7):2939-49. https://pubmed.ncbi.nlm.nih.gov/18426892/ | [target]
D-threo-PPMP is a potent inhibitor of glucosylceramide (GlcCer) synthase. |
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| Company Name: |
Creative Enzymes
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| Tel: |
1-516-855-7709 |
| Website: |
www.creative-enzymes.com |
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