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ChemicalBook--->CAS DataBase List--->1397195-80-0

1397195-80-0

1397195-80-0 Structure

1397195-80-0 Structure
IdentificationBack Directory
[Name]

SUMATRIPTAN-D6 HEMISUCCINATE
[CAS]

1397195-80-0
[Synonyms]

SUMATRIPTAN-D6 HEMISUCCINATE
[Molecular Formula]

C32H36D12N6O8S2
[MDL Number]

MFCD08063531
[MOL File]

1397195-80-0.mol
[Molecular Weight]

720.96
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: soluble
[form ]

A solid
Safety DataBack Directory
[Symbol(GHS) ]


GHS05
[Signal word ]

Danger
[Hazard statements ]

H318
[Precautionary statements ]

P280-P305+P351+P338-P310
Hazard InformationBack Directory
[Biological Activity]

Sumatriptan-d6 is intended for use as an internal standard for the quantification of sumatriptan by GC- or LC-MS. Sumatriptan is an agonist of the serotonin (5-HT) receptor subtypes 5-HT1B and 5-HT1D (IC50s = 9.3 and 7.3 nM, respectively).1 It also binds to the 5-HT1F receptor (IC50 = 17.8 nM). It induces vasoconstriction in isolated human middle meningeal arteries (EC50 = 89.9 nM), an effect that can be reduced by the 5-HT1B/1D receptor antagonists GR125743 and GR127935 . Sumatriptan reduces acute, but not chronic, mechanical hyperalgesia in a mouse model of pain induced by nitroglycerin, which is a known migraine trigger in humans.2 Formulations containing sumatriptan have been used in the treatment of migraine headache.
[References]

1.Razzaque, Z., Heald, M.A., Pickard, J.D., et al.Vasoconstriction in human isolated middle meningeal arteries: Determining the contribution of 5-HT1B- and 5-HT1F-receptor activationBr. J. Pharmacol.47(1)75-82(1999) 2.Pradhan, A., Smith, M.L., McGuire, B., et al.Characterization of a novel model of chronic migrainePain155(2)269-274(2014)
1397195-80-0 suppliers list
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