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ChemicalBook--->CAS DataBase List--->1392494-64-2

1392494-64-2

1392494-64-2 Structure

1392494-64-2 Structure
IdentificationBack Directory
[Name]

ML 252
[CAS]

1392494-64-2
[Synonyms]

ML 252
ML252 >=98% (HPLC)
(2S)-2-phenyl-N-(2-pyrrolidin-1-ylphenyl)butanamide
(S)-2-Phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide
Benzeneacetamide, α-ethyl-N-[2-(1-pyrrolidinyl)phenyl]-, (αS)-
[Molecular Formula]

C20H24N2O
[MDL Number]

MFCD25976917
[MOL File]

1392494-64-2.mol
[Molecular Weight]

308.42
Chemical PropertiesBack Directory
[storage temp. ]

2-8°C
[solubility ]

DMSO: soluble25mg/mL, clear
[form ]

powder
[color ]

light to dark purple
Safety DataBack Directory
[WGK Germany ]

3
Hazard InformationBack Directory
[Biological Activity]

ML252 is a potentbrain penetrant potassium channel Kv7.2 (KCNQ2) inhibitor with an IC50 of 69 nM. ML252 is only slightly selective over KCNQ3 and KCNQ4 but is over 40-fold selective for KCNQ2 vs KCNQ1unlike other KCNQ inbhibitors currently used. ML252 was also selective vs. >68 tested GPCRsion channelsand transporters. Potassium channel Kv7.2 has become a new target for Alzheimerμs Disease drug research because inhibiting it enhances acetylcholine release. SAR studies showed a small structural change from ethyl group to hydrogen resulted in a functional shift from antagonist to agonist activity (37EC50 of 170 nM)suggesting an interaction at a critical site for controlling KCNQ2 channel gating.
[storage]

Store at -20°C
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