Identification | Back Directory | [Name]
ML 252 | [CAS]
1392494-64-2 | [Synonyms]
ML 252 ML252 >=98% (HPLC) (2S)-2-phenyl-N-(2-pyrrolidin-1-ylphenyl)butanamide (S)-2-Phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide Benzeneacetamide, α-ethyl-N-[2-(1-pyrrolidinyl)phenyl]-, (αS)- | [Molecular Formula]
C20H24N2O | [MDL Number]
MFCD25976917 | [MOL File]
1392494-64-2.mol | [Molecular Weight]
308.42 |
Hazard Information | Back Directory | [Biological Activity]
ML252 is a potentbrain penetrant potassium channel Kv7.2 (KCNQ2) inhibitor with an IC50 of 69 nM. ML252 is only slightly selective over KCNQ3 and KCNQ4 but is over 40-fold selective for KCNQ2 vs KCNQ1unlike other KCNQ inbhibitors currently used. ML252 was also selective vs. >68 tested GPCRsion channelsand transporters. Potassium channel Kv7.2 has become a new target for Alzheimerμs Disease drug research because inhibiting it enhances acetylcholine release. SAR studies showed a small structural change from ethyl group to hydrogen resulted in a functional shift from antagonist to agonist activity (37EC50 of 170 nM)suggesting an interaction at a critical site for controlling KCNQ2 channel gating. | [storage]
Store at -20°C |
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Company Name: |
BOC Sciences
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Tel: |
1-631-485-4226; 16314854226 |
Website: |
https://www.bocsci.com |
Company Name: |
Energy Chemical
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Tel: |
021-58432009 400-005-6266 |
Website: |
http://www.energy-chemical.com |
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