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ChemicalBook--->CAS DataBase List--->1381769-23-8

1381769-23-8

1381769-23-8 Structure

1381769-23-8 Structure
IdentificationBack Directory
[Name]

TC-2153
[CAS]

1381769-23-8
[Synonyms]

TC-2153
TC-2153 >=95% (HPLC)
benzopentathiepin 8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine hydrochloride
[Molecular Formula]

C7H5ClF3NS5
[MDL Number]

MFCD28976193
[MOL File]

1381769-23-8.mol
[Molecular Weight]

355.87
Chemical PropertiesBack Directory
[storage temp. ]

-20°C
[form ]

powder
[color ]

white to beige
Hazard InformationBack Directory
[Biochem/physiol Actions]

TC-2153 is a potent inhibitor of STEP (STriatal-Enriched protein tyrosine Phosphatase) that forms a reversible covalent bond with the catalytic cysteine in STEP. TC-2153 increases tyrosine phosphorylation of STEP substrates ERK1/2, Pyk2, and GluN2B in cell cultures. TC-2153 improves cognitive function in transgenic AD mice.
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