| Identification | Back Directory | [Name]
Thiol-PEG2-acid | [CAS]
1379649-73-6 | [Synonyms]
SH-PEG2-COOH
HS-PEG2-COOH
Thiol-PEG2-acid
HS-PEG2-CH2CH2COOH
Propanoic acid, 3-[2-(2-mercaptoethoxy)ethoxy]- | [Molecular Formula]
C7H14O4S | [MDL Number]
MFCD24503001 | [MOL File]
1379649-73-6.mol | [Molecular Weight]
194.25 |
| Chemical Properties | Back Directory | [Boiling point ]
329.0±32.0 °C(Predicted) | [density ]
1.173±0.06 g/cm3(Predicted) | [storage temp. ]
Refrigerator, under inert atmosphere | [solubility ]
Chloroform (Sparingly), Methanol (Slightly) | [form ]
Oil | [pka]
4.27±0.10(Predicted) | [color ]
Colourless | [Stability:]
Air Sensitive |
| Hazard Information | Back Directory | [Description]
Thiol-PEG2-acid is a PEG linker containing a thiol group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The thiol group reacts with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | [Uses]
Thiol-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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