| Identification | Back Directory | [Name]
Mal-PEG2-acid | [CAS]
1374666-32-6 | [Synonyms]
Mal-PEG2-acid
Mal-NH-PEG2-acid
Mal-PEG2-CH2CH2COOH
Maleimide-PEG2-CH2CH2COOH
α-Maleimidyl-ω-propionyloxy poly(ethylene glycol)
3-[2-[2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy]ethoxy]propanoic Acid
3-[2-[2-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]propanoic acid
Propanoic acid, 3-[2-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]- | [Molecular Formula]
C11H15NO6 | [MDL Number]
MFCD23726620 | [MOL File]
1374666-32-6.mol | [Molecular Weight]
257.24 |
| Hazard Information | Back Directory | [Description]
Mal-PEG2-acid is a PEG linker containing a maleimide group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | [Biological Activity]
Mal-PEG2-acid is a non-cleavable ADC linker for the synthesis of antibody-drug conjugates (ADCs). It can bind to Tubulysin (HY-128914) and its cytotoxic derivatives activity. It can also be used as a PROTAC linker for PROTAC synthesis. | [in vitro]
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. | [target]
| Non-cleavable < span> | PEGs | |
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