| Identification | Back Directory | [Name]
LEE011 (succinate) | [CAS]
1374639-75-4 | [Synonyms]
LEE011 (succinate)
Ribociclib succite
Ribociclib succinate
Ribociclib Succinate (Kisqali)
RIBOCICLIB SUCCINATE (LEE011 SUCCINATE)
LEE-011 succinate salt, Ribociclib succinate salt
7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide succinate | [Molecular Formula]
C27H36N8O5 | [MOL File]
1374639-75-4.mol | [Molecular Weight]
552.64 |
| Chemical Properties | Back Directory | [Melting point ]
>160oC (dec.) | [storage temp. ]
Refrigerator | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
Pale Beige |
| Hazard Information | Back Directory | [Uses]
LEE011 is an orally bioavailable and highly specific CDK4/6 (cyclin-dependent kinase 4/6) inhibitor. LEE011 in combination with LGX818 (a V600E BRAF specific inhibitor) or BYL719 (a PIK3CA specific inhibitor) leads to robust anti-tumor activity in melanoma and breast cancer tumor models. |
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