| Identification | Back Directory | [Name]
5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDE | [CAS]
137206-97-4 | [Synonyms]
DPMQ
DMPQ2HCl
DMPQ DIHYDROCHLORIDE
5,7-dimethoxy-3-pyridin-4-ylquinoline
5,7-dimethoxy-3-(4-pyridinyl)quinoline
Quinoline, 5,7-dimethoxy-3-(4-pyridinyl)-
5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDE
5,7-DiMethoxy-3-(pyridin-4-yl)quinoline dihydrochloride | [Molecular Formula]
C16H14N2O2 | [MDL Number]
MFCD02262123 | [MOL File]
137206-97-4.mol | [Molecular Weight]
266.29 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at RT | [solubility ]
Soluble in DMSO (up to 1 mg/ml with warming) or in Water (up to 30 mg/ml). | [form ]
solid | [color ]
Yellow | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 2 months. |
| Hazard Information | Back Directory | [Description]
DMPQ 2HCl (137206-97-4) is a potent and selective inhibitor of PDGFRβ, IC50=80 nM. Greater than 100-fold more selective compared to EGFR, erB2, p56, PKA and PKC. Cell permeable. | [Uses]
DMPQ dihydrochloride is a selective an a potent inhibitor of human platelet-derived growth factor receptor β (PDGFRβ). | [Biological Activity]
A potent and selective inhibitor of human vascular β -type platelet derived growth factor receptor tyrosine kinase (PDGFR β ) (IC 50 = 80 nM). Displays > 100-fold selectivity over EGFR tyrosine kinase, erbB2, p56, protein kinase A and protein kinase C. | [References]
1) Dolle et al. (1994), Effects of xanthine derivatives on lipolysis and on adenosine 3′,5′-monophosphate phosphodiesterase activity; J. Med. Chem., 37 2627 |
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Creative Enzymes
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