| Identification | Back Directory | [Name]
4-Amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone | [CAS]
136891-12-8 | [Synonyms]
rac-cis-Lamivudine ((2RS,5SR)-Lamivudine)
4-Amino-1-(cis-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one
2(1H)-Pyrimidinone, 4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-, rel- | [Molecular Formula]
C8H11N3O3S | [MDL Number]
MFCD00870542 | [MOL File]
136891-12-8.mol | [Molecular Weight]
229.26 |
| Chemical Properties | Back Directory | [Melting point ]
187-188℃ | [Boiling point ]
475.4±55.0 °C(Predicted) | [density ]
1.73 | [storage temp. ]
2-8°C(protect from light) | [pka]
13.83±0.10(Predicted) |
| Hazard Information | Back Directory | [Definition]
ChEBI: Lamivudine is a monothioacetal that consists of cytosine having a (2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl moiety attached at position 1. An inhibitor of HIV-1 reverse transcriptase, it is used as an antiviral in the treatment of AIDS and hepatitis B. It has a role as a HIV-1 reverse transcriptase inhibitor, an antiviral drug, an anti-HBV agent, an allergen, a prodrug and an EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor. It is a monothioacetal, a primary alcohol, an oxacycle and a nucleoside analogue. It is functionally related to a cytosine. |
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