| Identification | Back Directory | [Name]
DG172 (dihydrochloride) | [CAS]
1361504-77-9 | [Synonyms]
DG-172
DG172 2HCl
DG-172 (hydrochloride)
DG172 (dihydrochloride)
(αZ)-2-Bromo-α-[[4-(4-methyl-1-piperazinyl)phenyl]methylene]benzeneacetonitrile dihydrochloride | [Molecular Formula]
C20H20BrN3?2HCl | [MDL Number]
MFCD29924728 | [MOL File]
1361504-77-9.mol | [Molecular Weight]
418.76 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
≤20mg/ml in ethanol;25mg/ml in DMSO;25mg/ml in dimethyl formamide | [form ]
crystalline solid | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Description]
DG-172 is an orally available inverse agonist of PPARβ/δ (IC50 = 27 nM), down-regulating transcription of ANGPTL4 in mouse myoblasts (IC50 = 9.5 nM). It alters the differentiation of bone marrow cells, augmenting GM-CSF-induced development into subsets of mature and immature dendritic cells. Inverse agonists of PPARβ/δ, including DG-172, inhibit cancer cell invasion through suppression of ANGPTL4 expression. | [Uses]
DG 172 Dihydrochloride is a potent peroxisome proliferator-activated receptor agonist and inhibit Angptl4 gene expression in mouse myoblasts. | [References]
[1]. lieber s, scheer f, meissner w, et al. (z)-2-(2-bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile (dg172): an orally bioavailable pparβ/δ-selective ligand with inverse agonistic properties. j med chem. 2012 mar 22;55(6):2858-68.
[2]. lieber s, scheer f, finkernagel f, et al. the inverse agonist dg172 triggers a pparβ/δ-independent myeloid lineage shift and promotes gm-csf/il-4-induced dendritic cell differentiation. mol pharmacol. 2015 feb;87(2):162-73.
[3]. adhikary t, brandt dt, kaddatz k, et al. inverse pparβ/δ agonists suppress oncogenic signaling to the angptl4 gene and inhibit cancer cell invasion. oncogene. 2013 oct 31;32(44):5241-52. |
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Musechem
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DC Chemicals
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