| Identification | Back Directory | [Name]
4-methoxy-3-methylaniline | [CAS]
136-90-3 | [Synonyms]
4-AMINO-2-METHYLANISOLE
4-METHOXY-3-METHYLANILINE
3-Methyl-4-methoxyaniline
4-methoxy-3-methylbenzenamine
3-Methyl-4-methoxybenzenamine
BenzenaMine, 4-Methoxy-3-Methyl-
4-AMINO-24-AMINO-2-METHYLANISOLE-METHYLANISOLE
4-AMino-2-Methylanisole[4-Methoxy-3-Methylaniline] | [Molecular Formula]
C8H11NO | [MDL Number]
MFCD07779234 | [MOL File]
136-90-3.mol | [Molecular Weight]
137.18 |
| Chemical Properties | Back Directory | [Melting point ]
57-60℃ | [Boiling point ]
252.03°C (rough estimate) | [density ]
1.0630 (rough estimate) | [refractive index ]
1.5360 (estimate) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
5.32±0.10(Predicted) | [color ]
Dark Red to Black |
| Hazard Information | Back Directory | [Uses]
4-Methoxy-3-methylaniline is used in preparation of triamine pyrimidine derivatives as antitumor agents. | [Synthesis]
The synthesis of 4-methoxy-3-methylaniline is as follows:
4-Methoxy-3-methyl-phenylamine10% Palladium on carbon (10% Pd/C) (1.5 g) was added to a solution of 1 -methoxy-2- methyl-4-nitrobenzene (9.5 g, 57 mmol) in methanol (100 ml_). The mixture was stirred under a hydrogen atmosphere (1 atm.) at room temperature for 16 h. The mixture was filtered through a pad of CELITE and the filtrate was evaporated in vacuo to yield 4- methoxy-3-methylphenylamine (8.0 g, 57 mmol, 100%).
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