| Identification | Back Directory | [Name]
koumine | [CAS]
1358-76-5 | [Synonyms]
koumine
(3R,7alpha,20alpha)-1,2,18,19-Tetradehydro-3,17-epoxy-7,20(2H,19H)cyclovobasan
7,20(2H,19H)-Cyclovobasan, 1,2,18,19-tetradehydro-3,17-epoxy-, (3R,7alpha,20alpha)-
6,4-(Epoxymethano)-3,11b-methano-11bH-pyrido[4,3-c]carbazole, 11c-ethenyl-1,2,3,4,4a,5,6,11c-octahydro-2-methyl-, (3S,4S,4aR,6R,11bS,11cS)- | [Molecular Formula]
C20H22N2O | [MDL Number]
MFCD11111448 | [MOL File]
1358-76-5.mol | [Molecular Weight]
306.407 |
| Chemical Properties | Back Directory | [Occurrence]
Koumine is an alkaloid isolated from Gelsemium elegans Benth. | [Melting point ]
168℃ | [Boiling point ]
436.5±45.0 °C(Predicted) | [density ]
1.42 | [storage temp. ]
Sealed in dry,2-8°C | [pka]
8.67±0.40(Predicted) |
| Hazard Information | Back Directory | [Description]
The Chinese drug 'Kou-wen', said to be derived from Gelsemium elegans Benth.,
is stated to contain this alkaloid which forms rhombic prisms from Me2 CO. It
has [α]23D - 265° (EtOH) and forms a crystalline hydrochloride, m.p. 255°C
(dec.) and a hydrobromide, m.p. 269°C (dec.). | [Uses]
Koumine is known to attenuate the lipopolysaccharide-stimulated inflammation in RAW264.7 macrophages. | [References]
Chou, Pak, Hou., Chin. 1. Physiol., 5, 345 (1931)
Chou, Wang, Chen., ibid, 8,40 (1934)
Chi, Kao, Huang., 1. Amer. Chem. Soc., 60, 1723 (1938) |
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