| Identification | Back Directory | [Name]
Argatroban Impurity 23 | [CAS]
1356847-56-7 | [Synonyms]
[2H3]-Argatroban
Argatroban-d3 (hydrochloride)
Argatroban-d3 (Mixture Of Diastereomers) | [Molecular Formula]
C23H33D3N6O5S | [MDL Number]
MFCD09839946 | [MOL File]
1356847-56-7.mol | [Molecular Weight]
511.653 |
| Hazard Information | Back Directory | [Description]
Argatroban-d3 is intended for use as an internal standard for the quantification of argatroban by GC- or LC-MS. Argatroban is a reversible inhibitor of thrombin (IC50s = 0.01 and 0.09 μM for the free and clot-bound forms, respectively). It is selective for thrombin over factor Xa, trypsin, plasmin, and tissue plasminogen activator (Kis = 0.0045, 53, 0.19, 25.7, and 87.7 μM, respectively). It inhibits thrombin-induced platelet aggregation in washed isolated guinea pig platelets with an IC50 value of 0.077 μM. Argatroban (3.2 mg/kg, s.c.) decreases thrombus formation in a guinea pig model of iron chloride-induced arterial thrombosis. Formulations containing argatroban have been used in the prevention or treatment of thrombosis in patients with heparin-induced thrombocytopenia. | [Uses]
Labelled synthetic thrombin inhibitor. Antithrombotic. |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
|
| Tel: |
58896805 |
| Website: |
http://www.approvedhomemanagement.com/ShowSupplierProductsList1748115/0.htm |
| Company Name: |
Pharma Affiliates
|
| Tel: |
172-5066494 |
| Website: |
http://www.approvedhomemanagement.com/ShowSupplierProductsList694812/0.htm |
|