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ChemicalBook--->CAS DataBase List--->135463-81-9

135463-81-9

135463-81-9 Structure

135463-81-9 Structure
IdentificationBack Directory
[Name]

COLURACETAM
[CAS]

135463-81-9
[Synonyms]

BCI-540
COLURACETAM
MKC-231;BCI-540
Coluracetam, >=99%
Coluracetam, MKC-231
COLURACETAM USP/EP/BP
top quality Coluracetam
MKC-231; MKC231; MKC 231
coluracetam cas: 135463-81-9
1-Pyrrolidineacetamide,2-oxo-N-(5,6,7,8-tetrahydro-2,3-dimethylfuro[2,3-b]quinolin-4-yl)-
2-oxo-N-(5,6,7,8-tetrahydro-2,3-dimethyl-furo[2,3-b]quinolin-4-yl)-1-pyrrolidineacetamide
N-(2,3-Dimethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)-2-(2-oxopyrrolidin-1-yl)acetamide
1-[N-(2,3-DiMethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)carbaMoylMethyl]pyrrolidin-2-one
[EINECS(EC#)]

1308068-626-2
[Molecular Formula]

C19H23N3O3
[MDL Number]

MFCD00901416
[MOL File]

135463-81-9.mol
[Molecular Weight]

341.4
Chemical PropertiesBack Directory
[Boiling point ]

634.1±55.0 °C(Predicted)
[density ]

1.291±0.06 g/cm3(Predicted)
[storage temp. ]

Sealed in dry,Room Temperature
[solubility ]

DMF: 1 mg/ml; DMSO: 2 mg/ml; Ethanol: 2 mg/ml; PBS (pH 7.2): insol
[form ]

A crystalline solid
[pka]

12.01±0.20(Predicted)
[color ]

White to off-white
[InChI]

InChI=1S/C19H23N3O3/c1-11-12(2)25-19-17(11)18(13-6-3-4-7-14(13)20-19)21-15(23)10-22-9-5-8-16(22)24/h3-10H2,1-2H3,(H,20,21,23)
[InChIKey]

PSPGQHXMUKWNDI-UHFFFAOYSA-N
[SMILES]

N1(CC(NC2C3=C(N=C4OC(C)=C(C)C4=2)CCCC3)=O)CCCC1=O
Hazard InformationBack Directory
[Uses]

Copiracetam can be used as a nootropic drug to treat memory and intellectual impairments caused by senile dementia, mild to moderate vascular dementia, trauma and other diseases, and to promote children's intellectual development; it also has antidepressant effects.
[Pharmacology]

Copiracetam has the ability to improve cognition by participating in the HACU process, increasing the rate-limiting step of synaptic intake of choline to synthesize the neurotransmitter acetylcholine, and increasing the activity of cholinergic neurons.
[in vitro]

Coluracetam (10(-10)-10(-6) moll), also known as MKC-231, significantly increased high affinity choline uptake (HACU) when it was incubated with the hippocampal synaptosomes of ethylcholine mustard aziridinium ion (AF64A) treated rats, but not of normal rats. MKC-231 did not affect the AChE activity, [3H]- quinuclidinyl benzilate binding, and [3H]-pirenzepine binding.
[in vivo]

Oral administration of MKC-231 (Coluracetam; 1-10 mg/kg) significantly improved the learning deficits in the Morris' water maze of AF64A-treated rats, but it did not produce any significant side effects, like tremor, salivation or hypothermia, which were observed in rats treated with high doses of tacrine [1]. In acute behavioral experiments, MKC-231 and THA had no significant effect on AF64A-induced memory deficits at any doses tested (0.3, 1.0 and 3.0 mg/kg), whereas Dup 996, at a dose of 1.0 mg/kg, significantly improved memory deficits. In chronic experiments, MKC-231 improved memory deficit at all doses tested (0.3, 1.0, or 3.0 mg/kg p.o., once daily for 11 days) and Dup 996 did so only at a dose of 3.0 mg/kg, whereas THA did not improve memory deficit at any doses tested.
Spectrum DetailBack Directory
[Spectrum Detail]

COLURACETAM(135463-81-9)1HNMR
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