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ChemicalBook--->CAS DataBase List--->135070-05-2

135070-05-2

135070-05-2 Structure

135070-05-2 Structure
IdentificationBack Directory
[Name]

E 4177
[CAS]

135070-05-2
[Synonyms]

E 4177
2-[4-[(2-cyclopropyl-7-methylimidazo[4,5-b]pyridin-3-yl)methyl]phenyl]benzoic acid
[Molecular Formula]

C24H21N3O2
[MDL Number]

MFCD00900702
[MOL File]

135070-05-2.mol
[Molecular Weight]

383.449
Hazard InformationBack Directory
[Description]

E-4177 is an angiotensin type 1 receptor antagonist potentially for the treatment of hypertension. In rat adrenal cortex and liver, E4177 competitively inhibited the specific binding of 125I-[Sar1,Ile8]Ang II, with IC50 being (5.2 +/- 1.0) x 10(-8) M for the adrenal cortex and (1.2 +/- 0.3) x 10(-7) M for the liver. These IC50 values were similar to those for losartan, which showed an IC50 of (6.0 +/- 0.9) x 10(-8) M for the adrenal cortex and (1.3 +/- 0.5) x 10(-7) M for the liver. E4177 is a potent AT1 Ang II-receptor antagonist that may be clinically useful for the treatment of cardiovascular diseases such as hypertension.
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