| Identification | Back Directory | [Name]
TETRAHYDROFOLIC ACID | [CAS]
135-16-0 | [Synonyms]
C00101
(6S)-Thfa
l-amino)benzoyl)
Tetrahydofolic acid
TETRAHYDROFOLIC ACID
Tetrahydrofolic acide
L-Tetrahydrofolic Acid
(6S)-Tetrahydrofolic acid
5,6,7,8-tetrahydrofolicacid
tetrahydropteroylglutamicacid
L-5,6,7,8-Tetrahydrofolic acid
Tetrahydropteroylglutaamic acid
(-)-L-5,6,7,8-Tetrahydrofolic acid
tetrahydrofolic acid sealed ampule
5,6,7,8-TETRAHYDROPTEROYL-L-GLUTAMIC ACID
tetrahydrofolic acid dihydrochloride dihydrate
-2-(4-(((2-Amino-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)
Tetrahydrofolic acid 5,6,7,8-Tetrahydropteroyl-L-glutamic acid
Tetrahydrofolic acid,5,6,7,8-Tetrahydropteroyl-L-glutamic acid, THF
glutamicacid,n-(p-(((2-amino-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)
L-Tetrahydrofolic Acid, synthesized on receipt of order. 95% MiniMuM purity when shipped.
N-[4-[[(2-AMino-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)Methyl]aMino]benzoyl]-L-glutaMic Acid
N-[4-[[(2-amino-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
2-[[4-[(2-amino-4-oxo-5,6,7,8-tetrahydro-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
(2S)-2-(4-(((2-aMino-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)Methyl)aMino)benzaMido)pentanedioic acid
(2S)-2-(4-(((2-Amino-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzamido)pentanedioic acid | [EINECS(EC#)]
205-181-1 | [Molecular Formula]
C19H23N7O6 | [MDL Number]
MFCD00135583 | [MOL File]
135-16-0.mol | [Molecular Weight]
445.43 |
| Chemical Properties | Back Directory | [Melting point ]
>162°C (dec.) | [Boiling point ]
555.12°C (rough estimate) | [density ]
1.4216 (rough estimate) | [vapor pressure ]
0Pa@25°C | [refractive index ]
1.6800 (estimate) | [storage temp. ]
−20°C
| [solubility ]
Aqueous Base (Slightly), DMSO (Slightly), Methanol (Slightly, Heated, Sonicated) | [form ]
powder
| [pka]
3.51±0.10(Predicted) | [color ]
off-white to tan
| [BRN ]
9238187 | [Stability:]
We have observed that this material decomposes steadily over time. Use immediately upon receipt. |
| Hazard Information | Back Directory | [Chemical Properties]
Light Tan Solid | [Uses]
A folic acid derivative and coenzyme involved in the metabolism of amino and nucleic acids.
We have observed that this material decomposes steadily over time. Use immediately upon receipt. | [Definition]
ChEBI: A derivative of folic acid in which the pteridine ring is fully reduced; it is the parent compound of a variety of coenzymes that serve as carriers of one-carbon groups in metabolic reactions. | [Flammability and Explosibility]
Notclassified(100%) | [Biochem/physiol Actions]
Tetrahydrofolic acid is the parent molecule of the folate derivatives that donate one-carbon units to amino acids, nucleic acids, and lipids. Tetrahydrofolate metabolites participate in the synthesis of purine and pyrimidine and in synthesis and conversion of amino acids | [Purification Methods]
Very high quality material is now available commercially, and it should be a white powder. It can be dried over P2O5 in a vacuum desiccator and stored in weighed aliquots in sealed ampoules. It is stable at room temperature in sealed ampoules for many months and for much more extended periods at -10o. When moist, it is extremely sensitive to air whereby it oxidises to the yellow 7,8-dihydro derivative. In solution it turns yellow in colour as it oxidises, and then particularly in the presence of acids it turns dark reddish brown in colour. Hence aqueous solutions should be frozen immediately when not in use. It is always advisable to add 2-mercaptoethanol (if it does not interfere with the procedure for which it is used) which stabilises it by depleting the solution of O2. The sulfate salt is more stable but is much less soluble. The best way to prepare standard solutions of this acid is to dissolve it in the desired buffer and estimate the concentration by UV absorption in pH 7 buffer at 297nm ( 22,000 M-1cm-1). If a sample is suspect, it is not advisable to purify it because it is likely to deteriorate further as “dry box” conditions are necessary. Either a new sample is purchased or one is freshly prepared from folic acid. It has the above pKa values. [Hafeti et al. Biochemical Preparations 7 89 1960, UV: Mathews & Huennekens J Biol Chem 235 3304 1960, Osborn & Huennekens J Biol Chem 233 969 1958, O'Dell et al. J Am Chem Soc 69 250 1947, Blakley Biochem J 6 5 331 1957, Asahi Yakugaku Zasshi (J Pharm Soc Jpn) 79 1548 1959, Beilstein 26 III/IV 3879.] |
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