| Identification | Back Directory | [Name]
Axitinib Impurity a | [CAS]
1347304-18-0 | [Synonyms]
Axitinib C
PF03482595)
Axitinib M12
Axitinib Sulfoxide
Axitinib Impurity a
Axitinib metabolite M12
Axitinib sulfoxide (AG028458
N-methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfinyl]benzamide
N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]benzamide
Benzamide, N-methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]-
Axitinib Impurity 5/Axitinib Sulfoxide/N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]-benzamide | [Molecular Formula]
C22H18N4O2S | [MDL Number]
MFCD30747237 | [MOL File]
1347304-18-0.mol | [Molecular Weight]
402.47 |
| Chemical Properties | Back Directory | [Melting point ]
>225 (dec.) | [Boiling point ]
720.6±60.0 °C(Predicted) | [density ]
1.43±0.1 g/cm3(Predicted) | [storage temp. ]
Refrigerator | [solubility ]
DMSO (Slightly), Methanol (Slightly, Heated) | [form ]
Solid | [pka]
11.70±0.40(Predicted) | [color ]
Light Yellow |
| Hazard Information | Back Directory | [Description]
Axitinib sulfoxide is a major inactive metabolite of the tyrosine kinase inhibitor axitinib . It is formed from axitinib primarily by the cytochrome P450 (CYP) isoform CYP3A4 with minor contributions from CYP3A5 and CYP2C19. | [Uses]
Axitinib Sulfoxide is a major metabolite of Axitinib (A794650), a tyrosine kinase inhibitor. Axitinib is used in cancer therapy. | [storage]
Store at -20°C |
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