| Identification | Back Directory | [Name]
Arginase inhibitor 1 | [CAS]
1345808-25-4 | [Synonyms]
Arginase inhibitor 1
1-Piperidinebutanoic acid, α-amino-α-(4-boronobutyl)-, (αR)-
(alphaR)-alpha-Amino-alpha-(4-boronobutyl)-1-piperidinebutanoic acid | [Molecular Formula]
C13H27BN2O4 | [MDL Number]
MFCD28167713 | [MOL File]
1345808-25-4.mol | [Molecular Weight]
286.18 |
| Chemical Properties | Back Directory | [Boiling point ]
523.0±60.0 °C(Predicted) | [density ]
1.147±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | [solubility ]
DMSO: 50 mg/ml; Water: 30 mg/ml | [form ]
Powder | [pka]
2.22±0.44(Predicted) | [color ]
White to gray |
| Hazard Information | Back Directory | [Description]
Arginase inhibitor 1 is an inhibitor of arginase I and II (IC50s = 223 and 509 nM, respectively, for the recombinant human enzymes). It decreases arginase I activity in CHOK cells expressing human arginase I (IC50 = 8 μM). Arginase inhibitor 1 (100 mg/kg, i.v.) reduces infarct size in a rat model of myocardial ischemia and reperfusion injury induced by left-main coronary artery occlusion. |
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SPIRO PHARMA
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www.spiropharma.com.cn |
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BOC Sciences
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Musechem
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DC Chemicals
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