| Identification | Back Directory | [Name]
Hydroxocobalamin | [CAS]
13422-51-0 | [Synonyms]
axion
axlon
ohb12
vibeden
cobalex
docclan
docelan
redisolh
lyovit-h
oxobemin
docevita
duradoce
hydrovit
depogamma
oh-duphar
vitadurin
docelvita
ciplaminh
OH-CBL HCL
duralta-12
hyxobamine
hydrobamine
neo-cytamen
neo-rojamin
primabaltrp
neo-macrabin
idrogrisevit
VITAMIN B12A
alphacobione
alpharedisol
VITAMIN B12B
hydrogrisevit
hydrocobalamin
Hydroxocobalam
HYDOXOCOBALAMIN
hydroxocobemine
hydroxycobalamin
hydroxo-cobalami
oxolamine(arcum)
HYDROXOCOBALAMIN
vitaminb(sub12a)
HYDROXOCOBALAMINE
hydroxycobalamine
hydroxyvitaminb12
Hydroxocobalamin CRS
HYDROXOCOBALAMIN,USP
AQUOCOBALAMIN CHLORIDE
Hydroxocobalamin (~90%)
Cyanocobalamin Impurity 13
VITAMIN B12A HYDROCHLORIDE
HYDROXOCOBALAMIN VITAMIN B12
High purity Hydroxocobalamin
HYDROXOCOBALAMIN HYDROCHLORIDE
HYDROXYCOBALAMIN HYDROCHLORIDE
HYDROXOCOBALAMINE HYDROCHLORIDE
ALPHAREDISOL (hydroxocobalaMin)
HydroxocobalaMin (VitaMin B12a)
Hydroxocobalamin/VitaminB12Cp2000
hydroxycobalamin (both acetate and HCl)
α-[5,6-Dimethylbenzimidazolyl] hydroxocobamide
alpha-(5,6-dimethylbenzimidazolyl)hydroxocobamide
Hydroxocobalamin/Hydrovit/vitamin B12 CAS NO.13422-51-0
sterwith5,6-dimethyl-1-alpha-d-ribofuranosylbenzimidazole
erwith5,6-dimethyl-1-alpha-d-ribofuranosyl-1h-benzimidazole
Hydroxocobalamin Acetate/Hydroxocobalamin HCL (Vitamin B12)
ALPHA-(5,6-DIMETHYLBENZIMIDAZOLYL)HYDROXOCOBAMIDE HYDROCHLORIDE
Coalpha-[alpha-(5,6-dimethylbenzimidazolyl)]-Cobeta-hydroxocobamide
cobinamide,dihydroxide,dihydrogenphosphate(ester),mono(innersalt),3’-e
cobinamide,dihydroxide,dihydrogenphosphate(ester),mono(innersalt),3’-est
cobinamidehydroxidephosphate3’-esterwith5,6-dimethyl-1-alpha-d-ribofuranos
CobinaMide,Co-hydroxy-, f-(dihydrogen phosphate), inner salt, 3'-ester with(5,6-diMethyl-1-a-D-ribofuranosyl-1H-benziMidazole-kN3)
Cobinamide, Co-hydroxy-, f-(dihydrogen phosphate), inner salt, 3-ester with (5,6-dimethyl-1-.alpha.-D-ribofuranosyl-1H-benzimidazole-.kappa.N3) | [EINECS(EC#)]
236-534-8 | [Molecular Formula]
C62H90ClCoN13O15P | [MDL Number]
MFCD00167463 | [MOL File]
13422-51-0.mol | [Molecular Weight]
1382.82 |
| Questions And Answer | Back Directory | [Uses]
Hydroxocobalamin is an intermediate in the synthesis of Nitritocobalamin is a useful synthetic intermediate in the synthesis of Hydroxocobalamin Acetate; a physiological analog of vitamin B12 where the CN group is replaced with OH. Exists in aqueous solution as an equilibrium mixture of the hydroxy isomer and the ionic aqua isomer (aquacobalamin). Precursor of the coenzymes methylcobalamin and cobamamide. Coordination Compound. Vitamin (hematopoietic). |
| Hazard Information | Back Directory | [Uses]
Vitamin (hematopoietic). | [Originator]
Alpha-Redisol,MSD,US,1962 | [Manufacturing Process]
A solution containing 26.3 mg of vitamin B12 in 15 ml of water was shaken
with 78 mg of platinum oxide catalyst and hydrogen gas under substantially
atmospheric pressure at 25°C for 20 hours. Hydrogen was absorbed. During
the absorption of hydrogen the color of the solution changed from red to
brown. The solution was separated from the catalyst and evaporated to
dryness in vacuo. The residue was then dissolved in 1 ml of water and then
diluted with about 6 ml of acetone.
After standing for several hours a small amount of precipitate (about 2 to 3
mg) was formed and was then separated from the solution. This solution was
diluted with an additional 2 ml of acetone and again allowed to stand for
several hours. During this time about 4 to 5 mg of noncrystalline precipitate
formed. This solid was separated from the solution and an additional 2 ml of
acetone was added to the solution. On standing, vitamin B12a began to
crystallize in the form of red needles. After standing for 24 hours, the
crystalline material was separated, yield 12 mg. By further dilution of the
mother liquor with acetone additional crystalline precipitate formed (from US
Patent 2,738,302). | [Therapeutic Function]
Hematopoietic vitamin | [Side effects]
Hydroxocobalamin is generally a well-tolerated drug. The adverse effects stem from hypersensitivity reactions to cobalt or other components of the hydroxocobalamin injection. These adverse effects include; exanthema (rash), Itching, fever, nausea, dizziness, rigors, and hot flushes. Anaphylaxis is rare. |
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