| Identification | Back Directory | [Name]
Ethanone, 1-[5-(hydroxymethyl)-1H-imidazol-2-yl]- | [CAS]
1331754-16-5 | [Synonyms]
Ethanone, 1-[5-(hydroxymethyl)-1H-imidazol-2-yl]- | [Molecular Formula]
C6H8N2O2 | [MDL Number]
MFCD28675904 | [MOL File]
1331754-16-5.mol | [Molecular Weight]
140.14 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml,DMSO: 30 mg/ml,PBS (pH 7.2): 10 mg/ml | [form ]
A crystalline solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Biological Activity]
A6770 is an inhibitor of sphingosine-1-phosphate (S1P) lyase.1 It induces accumulation of [3H]sphinganine-1-phosphate ([3H]dhS1P), an S1P lyase substrate, in IT-79MTNC3 cells that endogenously express high levels of S1P lyase (EC50 = <0.01 μM), an effect that is reduced in the presence of vitamin B6 (EC50 = <100 μM). | [References]
1.Ohtoyo, M., Tamura, M., Machinaga, N., et al.Scintillation proximity assay to detect the changes in cellular dihydrosphingosine 1-phosphate levelsLipids51(10)1207-1216(2016)
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