| Identification | Back Directory | [Name]
PDZ1 DOMAIN INHIBITOR PEPTIDE | [CAS]
1315378-73-4 | [Synonyms]
PDZ1 DOMAIN INHIBITOR PEPTIDE
L-Valine, L-tyrosyl-L-lysyl-L-lysyl-L-threonyl-L-α-glutamyl-L-alanyl-, (5→3)-lactam | [Molecular Formula]
C38H61N9O11 | [MDL Number]
MFCD07785500 | [MOL File]
1315378-73-4.mol | [Molecular Weight]
819.94 |
| Chemical Properties | Back Directory | [Boiling point ]
1304.2±65.0 °C(Predicted) | [density ]
1.32±0.1 g/cm3(Predicted) | [storage temp. ]
Desiccate at -20°C | [solubility ]
Soluble to 1 mg/ml in 5% acetonitrile / Water and to 4 mg/ml in DMSO | [form ]
Solid | [pka]
3.36±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
PDZ1 Domain inhibitor peptide, a cyclic peptide, incorporates a β-Ala lactam side chain linker and targets the PDZ1 domains of the postsynaptic density protein 95 (PSD-95). PDZ1 Domain inhibitor peptide disrupts the GluR6/PSD-95 interaction and is very efficient in competing against the C terminus of GluR6 for the PDZ1 domain[1]. | [storage]
Desiccate at -20°C | [References]
[1] Andrea Piserchio, et al. Targeting specific PDZ domains of PSD-95; structural basis for enhanced affinity and enzymatic stability of a cyclic peptide. Chem Biol. 2004 Apr;11(4):469-73. DOI:10.1016/j.chembiol.2004.03.013 |
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