| Identification | Back Directory | [Name]
Iothalamate meglumine | [CAS]
13087-53-1 | [Synonyms]
Meglumine iotalamate
Iothalamate Meglumine
N-Methylglucamine salt
Iotalamic acid meglumine
Iothalamic acid·meglumine
Iotalamic acid meglumine salt
iothalamic acid meglumine salt
Meglumine iothalamate injection
Iothalamate meglumine USP/EP/BP
1-deoxy-1-(methylamino)-D-glucitol 3-(acetylamino)-2,4,6-triiodo-5-[(methylamino)carbonyl]benzoate
D-Glucitol, 1-deoxy-1-(methylamino)-, 3-(acetylamino)-2,4,6-triiodo- 5-[(methylamino)carbonyl]benzoate (salt) | [EINECS(EC#)]
235-998-9 | [Molecular Formula]
C11H9I3N2O4.C7H17NO5 | [MDL Number]
MFCD01717601 | [MOL File]
13087-53-1.mol | [Molecular Weight]
809.115 |
| Hazard Information | Back Directory | [Originator]
Conray,Mallinckrodt Inc.,US,1962 | [Uses]
Diagnostic aid (radiopaque medium). | [Definition]
ChEBI: Iothalamate meglumine is an amidobenzoic acid. | [Manufacturing Process]
Crude 5-amino-2,4,6-triiodo-N-methylisophthalamic acid (21.0 g) was
dissolved in warm dimethylacetamide (40 ml) and acetic anhydride (30 ml)
and concentrated sulfuric acid (2 drops) were added. This solution was heated
on the steam bath for 2 hours, then heated at 110°C for 5 minutes, then
cooled. Water and ammonium hydroxide were added to destroy the excess
acetic anhydride, after which the mixture was evaporated to a volume of 50
ml. The cooled solution was acidified with concentrated hydrochloric acid and
a tan solid was collected. The crude product was dissolved in 100 ml of water
containing a slight excess of sodium hydroxide. The pH was adjusted to 4.5
with acetic acid, and the solution was treated with charcoal. The colorless
solution was acidified with concentrated hydrochloric acid and cooled, and the
precipitate was filtered off and dried under reduced pressure. The resulting 5-
acetamido-2,4,6-triiodo-N-methylisophthalamic acid decomposes about 285°C
and does not melt below 300°C.
5-acetamido-2,4,6-triiodo-N-methylisophthalamic acid was slurried in water
and dissolved by the addition of an equivalent quantity of N-methylglucamine.
The solution was evaporated to dryness to yield the meglumate salt of 5-
acetamido-2,4,6-triiodo-N-methylisophthalamic acid. | [Brand name]
Conray(Mallinckrodt). | [Therapeutic Function]
Diagnostic aid (radiopaque medium) | [General Description]
Iothalamate meglumineis a high-osmolar, ionic monomer with 47% boundiodine content. Conray is indicated for use in angiography,excretory urography, arthrography, cholangiography, endoscopicretrograde cholangiopancreatography, and variousCT procedures. |
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