| Identification | Back Directory | [Name]
3-HYDRAZINO-QUINOXALINE-2-THIOL | [CAS]
13080-21-2 | [Synonyms]
AKOS BBS-00008251
CHEMBRDG-BB 5215319
3-HYDRAZINO-QUINOXALINE-2-THIOL
3-Hydrazinylquinoxaline-2-thiol
2(1H)-Quinoxalinethione, 3-hydrazinyl-
3-hydrazinoquinoxaline-2-thiol(SALTDATA: FREE) | [Molecular Formula]
C8H8N4S | [MDL Number]
MFCD00457014 | [MOL File]
13080-21-2.mol | [Molecular Weight]
192.24 |
| Chemical Properties | Back Directory | [Melting point ]
254 °C (decomp)(Solv: ethanol (64-17-5)) | [Boiling point ]
376.1±25.0 °C(Predicted) | [density ]
1.55±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
7.91±0.20(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Biological Activity]
HPi1 is a potent, selective and orally active antibacterial agent against Helicobacter pylori with IC50 of 0.24 μM and MIC of 0.08-0.16 μg/mL. It is inactive against other bacteria, including the enteric bacteria Lactobacillus casei, Lactobacillus reuteri and Bifidobacterium longum. | [in vitro]
The MIC against H. pylori isolates ranged from 0.002-0.032 μg/mL (0.01-0.17 μM) in the agar dilution assay. HPi1 is effective against the clarithromycin-resistant strains ARHp172 (MIC of 0.004–0.016 μg/mL) and ARHp246 (MIC of 0.008–0.032 μg/mL).
HPi1 has some activity against the Bacteroides species , but at concentrations at least 18- fold higher than the H. pylori MIC. More potent activity is detected for Campylobacter jejuni with an MIC of 0.3 μg/mL.
HPi1 has good physicochemical and pharmacological properties, including determining the aqueous solubility (19 μg/mL), human plasma protein binding (93% bound), stability with human liver microsomes (T 1/2 of 1.3 hours) and the ability to passively permeate membranes. | [target]
IC50: 0.24 μM ( Helicobacter pylori )
MIC: 0.08-0.16 μg/mL ( Helicobacter pylori ) |
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