| Identification | Back Directory | [Name]
MSA-2 | [CAS]
129425-81-6 | [Synonyms]
MSA-2
Benzo[b]thiophene-2-butanoic acid, 5,6-dimethoxy-γ-oxo- | [Molecular Formula]
C14H14O5S | [MDL Number]
MFCD32640674 | [MOL File]
129425-81-6.mol | [Molecular Weight]
294.32 |
| Chemical Properties | Back Directory | [Boiling point ]
509.3±50.0 °C(Predicted) | [density ]
1.336±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
DMSO: 125 mg/mL (424.71 mM) | [form ]
A crystalline solid | [pka]
4.35±0.17(Predicted) | [color ]
Light yellow to brown |
| Hazard Information | Back Directory | [Description]
MSA-2 was identified in a phenotypic screen for a chemical inducer of interferon beta secretion. In cell-free assays, MSA-2 binds to human and mouse STING. In tumor-bearing mice, MSA-2 induced elevated interferon-beta in plasma and tumors through two routes of administration. | [Uses]
MSA-2 is an oral non-nucleotide STING agonist with EC50 of 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively. | [storage]
Store at -20°C |
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