| Identification | Back Directory | [Name]
DPQ | [CAS]
129075-73-6 | [Synonyms]
DPQ
DMEM(Low Glucose)
PARP Inhibitor III, DPQ
PARP Inhibitor III, DPQ - CAS 129075-73-6 - Calbiochem
3,4-DIHYDRO-5[4-(1-PIPERIDINYL)BUTOXYL]-1(2H)-ISOQUINOLINE
3,4-DIHYDRO-5[4-(1-PIPERINDINYL)BUTOXY]-1(2H)-ISOQUINOLINE
5-(4-piperidin-1-ylbutoxy)-3,4-dihydro-2H-isoquinolin-1-one
3,4-DIHYDRO-5-[4-(1-PIPERIDINYL)BUTOXY]-1(2H)-ISOQUINOLINONE
3,4-DIHYDRO-5-[4-(1-PIPERIDINYL)BUTOXYL]-1(2H)-ISOQUINOLINONE
1(2H)-Isoquinolinone, 3,4-dihydro-5-[4-(1-piperidinyl)butoxy]-
5-[4-(1-PIPERIDINYL)-BUTYLOXY]-1,2,3,4-TETRAHYDROISOQUINOLIN-1-ONE | [Molecular Formula]
C18H26N2O2 | [MDL Number]
MFCD02258932 | [MOL File]
129075-73-6.mol | [Molecular Weight]
302.41 |
| Chemical Properties | Back Directory | [Melting point ]
107-109° | [Boiling point ]
528.8±50.0 °C(Predicted) | [density ]
1.096±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: Soluble | [form ]
solid | [pka]
14.54±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species. DPQ is a potent inhibitor of PARPs, inhibiting PARP1 with an IC50 value of 40 nM. It is approximately 10-fold less potent against PARP2. DPQ can be used in either cells or in animals. | [Uses]
3,4-Dihydro-5-[4-(1-piperidinyl)butoxy]-1(2H)-isoquinolinone is a potent inhibitor of poly(ADP-ribose) polymerases, a family of enzymes that plays a crucial role in DNA repair and apoptosis in respons
e to reactive oxygen and nitrogen species. | [Uses]
DPQ has been used as a PARP1 (poly(ADP-ribose) polymerase 1) inhibitor in in vivo studies to determine the loss of γ-H2AX (H2A histone family member X) upon irradiation. | [Uses]
Reagent for inhibition of PARP. | [Biochem/physiol Actions]
3,4-Dihydro-5-[4-(1-piperidinyl)butoxyl]-1(2H)-isoquinolinone (DPQ) is known to decrease the PARP 1 (poly(ADP-ribose) polymerase 1) mediated apoptosis under the influence of ischemia. It is considered as more effective inhibitor than the traditionally used PARP1 inhibitor 3-aminobenzamide. | [storage]
+4°C |
|
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Sigma-Aldrich
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BOC Sciences
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www.bocsci.com |
| Company Name: |
Energy Chemical
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021-58432009 400-005-6266 |
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http://www.energy-chemical.com |
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