| Identification | Back Directory | [Name]
Urea, N-[3,5-dichloro-4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]-N'-[3-(trifluoromethyl)phenyl]- | [CAS]
1268490-12-5 | [Synonyms]
GSK329
T24109
GSK-329
GSK 329
Urea, N-[3,5-dichloro-4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]-N'-[3-(trifluoromethyl)phenyl]- | [Molecular Formula]
C19H14Cl2F3N5O2 | [MOL File]
1268490-12-5.mol | [Molecular Weight]
472.25 |
| Chemical Properties | Back Directory | [Boiling point ]
471.0±45.0 °C(Predicted) | [density ]
1.554±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
DMSO : 250 mg/mL (529.38 mM; Need ultrasonic) | [form ]
Solid | [pka]
12.00±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Biological Activity]
GSK329 is a potent and selective diarylurea inhibitor of the cardiac-specific kinase TNNI3K. GSK329 exhibits positive cardioprotective outcomes in the model of ischemia/reperfusion cardiac injury[1]. | [storage]
4°C, protect from light | [References]
[1]. Patterson JR, et, al. Identification of Diarylurea Inhibitors of the Cardiac-Specific Kinase TNNI3K by Designing Selectivity Against VEGFR2, p38α, and B-Raf. J Med Chem. 2021 Nov 11;64(21):15651-15670. |
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| Company Name: |
DC Chemicals
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021-58447131 13564518121 |
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http://www.approvedhomemanagement.com/ShowSupplierProductsList927327/0.htm |
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