| Identification | Back Directory | [Name]
Etelcalcetide | [CAS]
1262780-97-1 | [Synonyms]
Etelcalcetide
AMG-416 (Velcalcetide)
D-Argininamide, N-acetyl-D-cysteinyl-D-alanyl-D-arginyl-D-arginyl-D-arginyl-D-alanyl-, disulfide with L-cysteine | [Molecular Formula]
C38H73N21O10S2 | [MDL Number]
MFCD31735128 | [MOL File]
1262780-97-1.mol | [Molecular Weight]
1048.25 |
| Chemical Properties | Back Directory | [density ]
1.58±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
2.01±0.10(Predicted) | [Sequence]
H-Cys(1)-OH,Ac-D-Cys(1)-D-Ala-D-Arg-D-Arg-D-Arg-D-Ala-D-Arg-NH2(Disulfide bridge Cys1-(D-Cys1))/C(1),Ac-（D-C（1）-（D-A）-（D-R）-（D-R）-（D-R）-（D-A）-（D-R）-NH2(Disulfide bridge Cys1-(D-Cys1)) |
| Hazard Information | Back Directory | [Uses]
N-Acetyl-D-cysteinyl-D-alanyl-D-arginyl-D-arginyl-D-arginyl-D-alanyl- D-Argininamide-L-cysteine Disulfide is a useful research chemical used in the treatment of chronic kidney disease-??mineral and bone disorder. | [Definition]
ChEBI: Etelcalcetide is an oligopeptide. | [Clinical Use]
Synthetic peptide calcimimetic agent:Treatment of secondary hyperparathyroidism in
patients on haemodialysis | [Drug interactions]
Potentially hazardous interactions with other drugs
Avoid with cinacalcet. | [Metabolism]
Etelcalcetide is biotransformed in blood by reversible
disulphide exchange with endogenous thiols to
predominantly form conjugate with serum albumin |
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