| Identification | Back Directory | [Name]
vomicine | [CAS]
125-15-5 | [Synonyms]
C09255
Struxine
vomicine
Strychnicine
12-Hydroxy-N-methylpseudostrychinine
4-Hydroxy-19-methyl-16,19-secostrychinidine-10,16-dione
12H-6a,4-(Ethaniminomethano)indolo[3,2,1-ij]oxepino[2,3,4-de]quinoline-6,12(2H)-dione, 4a,5,13,13a,13b,13c-hexahydro-10-hydroxy-16-methyl-, (4aR,6aS,13aS,13bR,13cS)- | [Molecular Formula]
C22H24N2O4 | [MDL Number]
MFCD00033661 | [MOL File]
125-15-5.mol | [Molecular Weight]
380.44 |
| Chemical Properties | Back Directory | [Melting point ]
286-290℃ (dec.) | [alpha ]
D22 +80° (c = 0.5 in alc) | [Boiling point ]
508.07°C (rough estimate) | [density ]
1.44±0.1 g/cm3 (20 ºC 760 Torr) | [refractive index ]
1.6500 (estimate) | [form ]
Solid | [pka]
9.18±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Schaefer has obtained this base from old seeds of Strychnos Nux-vomica which
had deteriorated where is occurs to the extent of about 0.1 per cent. It forms
colourless crystals from EtOH which become yellow on exposure to light. With
H2S04 it gives a colourless solution that becomes green on the addition of
potassium dichromate. From the available evidence it seems likely that it is not a
true alkaloid but a decomposition product of either strychnine or brucine. | [Uses]
Vomicine is an antiplasmoidal alkaloid extracted from the stem bark of Strychnos malacoclados and is useful against malaria. | [Definition]
ChEBI: Vomicine is a member of carbazoles. | [References]
Schaefer.,J. Amer. Pharm. Assoc., 3,1677 (1914) |
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